The noticed not enough a big accumulation of PHN in brain next the intraventricular administration of (+)-amphetamine and the development of considerable amounts of PHN from (+)-POH in Mind tissue in vivo supports the see the aromatic hydroxylation of amphetamine pursuing its systemic administration occurs predominantly during the periphery, and that POH is then transported from the blood-Mind barrier, taken up by noradrenergic neurones in Mind where (+)-POH is converted while in the storage vesicles by dopamine β-hydroxylase to PHN. ^
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